Tired and Wired Bundle

Tired and Wired Bundle

Original price was: $180.30.Current price is: $165.42.

The Tired and Wired Bundle is the perfect solution for those who are feeling both exhausted and anxious. The bundle includes four powerful supplements: Adrenal Support, Relax Magnesium Support, 5HTP Support, and GABA Support.


Tired and Wired Bundle Includes:

  • Adrenal Support, 90 capsules. Dr. Doni’s Adrenal Support is a combination of standardized herbs and nutrients which are known to contribute to rejuvenating the adrenals.
  • Be Happy 5HTP Support is a synergistic formula of 5-hydroxytryptophan (50 mg) and vitamin B6 (10 mg) per serving for supporting overall neurotransmitter metabolism by providing precursors of serotonin.
  • GABA Support provides calming neurotransmitter support to promote relaxation, positive mood, and restful sleep.
  • Relax Magnesium Support features the unique, patented, chelated mineral Magtein®, which contains magnesium that is chelated to threonic acid (magnesium L-threonate).

Tired and Wired Bundle


A Tired and Wired type has low cortisol with high adrenaline. Cortisol and adrenaline are our stress hormones.

Reason Why:

This is caused by exposure to recurrent or chronic stress. The stress response system (called the HPA axis) is not recovering, as it should, and your adrenal glands are becoming less able to keep up with the demand for cortisol. Meanwhile your body may be metabolizing adrenaline more slowly, resulting in a high level.

Tired and Wired Bundle Treatment:

Not to worry, though. Now that we know your body needs help to reduce adrenaline and increase cortisol, we can use natural substances that are non-addictive and have no known side effects. Of course, if you are allergic to these substances, you’ll need to choose a different option.

First things first, we need to help your body metabolize adrenaline. We can do that with magnesium.

#1 Magnesium:

  • Magnesium and the Threonate form in particular, is a mineral and essential cofactor for the metabolism of adrenaline (and many other metabolic pathways in the body), also known as norepinephrine and epinephrine.
  • Magnesium deficiency is one of the most common nutrient deficiencies that slows down the COMT enzyme metabolism, leaving higher adrenaline levels.
  • Dosage: 200 and 500 mg per day.

See Study

Next, and before taking substances to support the low cortisol, and consistent with the Stress Recovery Protocol, Dr. Doni has found that it is essential to also support the calming (inhibitory) neurotransmitters, GABA and Serotonin.

These neurotransmitters are often depleted by stress exposure, and when we don’t have enough, it leaves us vulnerable to experiencing the effects of stress.

To truly recover and get ahead of stress, it is important to ensure adequate calming neurotransmitters, which can be done using a clinical nutrition protocol known as amino acid therapy. Amino acids are the metabolic building blocks of protein.

We access amino acids via protein in our diet which are transformed into neurotransmitters in the human digestive tract. When the diet is low in protein, and the digestion and microbiome are disrupted (often due to stress), we don’t make adequate amounts of these neurotransmitters to keep up with our stress exposure.

These are the natural substances we can take as part of the Stress Recovery Protocol:

#2 5HTP (5-Hydrodroxytryptophan):

  • It’s used as a precursor to serotonin.
  • Dosage: 50 mg to 200 mg per day, taken with food to start, and often preferred to take at bedtime.
  • If you are taking an SSRI or SNRI or other psychotropic medicine, it is important to work with a clinical nutritionist who understands the use of amino acids with medications.

See Study supporting Tired and Wired Bundle

#3 L-Theanine:

  • This amino acid, and GABA itself can be used to support GABA levels.
  • Dosage: 100 mg to 600 mg of L-Theanine per day, and 200 mg to 600 mg of GABA, spread out through the day.

See Study supporting Tired and Wired Bundle

Meanwhile, it’s important to work on healing the gut to improve the body’s ability to make GABA and serotonin going forward.

And finally, once things have calmed out of stress mode, then we can support your adrenal glands to make more cortisol. We can use natural substances that are known to support adrenal function:

#4 Herbs and Nutrients:

  • Vitamin C: 500 mg to 1,000 mg once or twice per day.
  • Vitamin B5 (Pantothenic acid): 500 mg to 1,000 mg once or twice per day.
  • Herbs including holy basil (often referred to as tulsi), rhodiola, herbal licorice and eleutherococcus (Siberian ginseng).
  • The above are known to increase production of cortisol and potentially adrenaline as well.

See Study

You can get these all in one supplement, which is best to take in the morning, when cortisol levels should naturally increase.

The above herbs and nutrients are known to increase production of cortisol and potentially adrenaline as well so have magnesium on hand to take in case your adrenaline increases too much again.

Tired and Wired Bundle Recommendations

  • Whenever beginning to take supplements – whether nutrients, herbs, or other substances – it is important to start one at a time and at a low dose so that you can observe how your body responds.
  • If you notice any new symptoms, such as a rash or headache, stop taking the new substance and talk with your naturopathic doctor or functional medicine practitioner to help guide you.
  • Once you have a sense that a substance is okay for you, you can add the next, and then the goal is to fine-tune your doses based on your individual needs.
  • Doni encourages you to use your SelfC.A.R.E. Notebook to track your 5 body signals – energy, mood, sleep, focus, and body – each day and optimize your doses.