Doctor Doni

How to Support Your Immune System (Without Causing a Cytokine Storm)

Your immune system is more important than ever right now. When stress levels rise, it disrupts healthy immune function. Here are 6 steps to help your body rebalance your immune response.

How to Support Your Immune System (Especially Now)

I hear from so many patients who have imbalanced immune responses. Whether they are susceptible to viral infections (such as EBV and HPV), or they have allergic reactions and histamine intolerance, or even autoimmunity of various types, all of these situations are caused by a less-than-optimal immune system. Most practitioners come from the perspective of wanting to suppress the immune system (including allergists and rheumatologists) or to force the body to attack the invading substance. Hardly ever will you hear the strategy of wanting to bring the immune system back to healthy function.

The immune system is quite complex and not as well understood as we might think. It is not as simple as pushing it one way or another. And it is not stuck where it is now. My body is a perfect example of that. I experienced severe allergies for over 20 years, and now they are gone. I did this not by suppressing my immune system (such as with steroids), and not by forcing it to do what we think it should do (such as with allergy shots). Instead, I supported it in returning to optimal functioning with what is now known as my Stress Recovery Protocol.

Our immune system is built to protect us. Our unique genetics can lead us to be more susceptible to variations in how our immune system functions. For some, that means being more likely to have allergies, or autoimmunity, or immune deficiencies. But what is important to know is that our genetic tendencies are turned on by stress. Once we help your body recover from stress, your immune system can go back to doing what it does best, protecting you and helping your body heal.

I’ll show you how to get your immune system back on track in this article. The first step is to understand your immune system.

What Is the Immune System?

The immune system is comprised of several different types of white blood cells, including B cells and T cells (which are lymphocytes), as well as mast cells. There are MANY signaling substances – I refer to them as “messengers” – including antibodies, histamines, cytokines, and more.

Unlike other parts of the body, the immune system is not located in one place. It is able to be anywhere in the body, anytime it is needed to protect us from foreign substances – a bacteria, virus, yeast, parasite, or allergen.

The white blood cells are made in the bone marrow, and each play a different role in the immune system. B cells make antibodies (IgA, IgG, IgE, etc) and help to “flag” invading cells so the rest of the immune system knows what to attack. T cells, which finish development in the thymus gland, can directly kill infected cells and cancer cells, and make cytokines that communicate to the rest of the immune system to fend off viruses, bacteria and any other abnormal cells (cancer cells) or a foreign substances. Mast cells, which are especially important in the intestines, directly eliminate pathogens and release histamine, cytokines, and other messengers to signal to the rest of the immune system.

Working together, this whole process creates inflammation and oxidative stress, which is necessary to some degree, in order to address the issue, and to stimulate healing. The immune system is also able to turn itself off and calm back down, to be ready for the next potential issue.

Essentially, your immune system is built to protect you from viruses and the like. 

It is when inflammation is over the top, and doesn’t turn off when it should, or is over-reactive and over-protective to substances that aren’t really an issue, and/or gets confused and starts protecting us from our own cells and tissue, that trouble ensues.

What Is a Cytokine Storm?

A cytokine storm is an overproduction inflammatory cytokines, which attract even more cells that end up attacking and damaging healthy cells in the body.

You may have heard this term (cytokine storm) being used lately in regards to COVID-19 (Coronavirus), but that’s not the only time a cytokine storm is known to occur. Other viruses, as well as cancer and autoimmunity can also trigger an overproduction of cytokines, and the resultant inflammation, oxidative stress, and tissue damage.

Immunosuppressive medications have been developed to stop this kind of cytokine over-responsiveness. They are used in the treatment of autoimmune conditions and cancer. There is a downside though. These medications are also associated with an increased risk of infection and cancer. In some cases, the benefits outweigh the risks. However, these patients need to be monitored carefully, and the medications may only work for a period of time.

Another “messenger” in the inflammatory response is called bradykinin. Bradykinin is produced at the site of an injury or infection and signals for help, and for pain. Recent studies have indicated that a “bradykinin storm” is involved with COVID-19. When bradykinin levels increase (because they are not being broken down properly), it causes blood vessels to become “leaky” (similar to leaky gut), leading to fluid leaking into the lungs, dizziness, fatigue. It can also cause low blood pressure and irregular heart beats, all of which are common symptoms with COVID-19.

We can help minimize occurrence or avoid all of the above by having a balanced level of immunity. We want to see not too much (cytokine or bradykinin storm and autoimmunities), and not too little (sickness and no protection against viruses). To do that, we need to give your body what it needs to recover from stress (and oxidative stress) so that your immune system can work when you need it, and turn off when its work is done.

How Stress Affects the Immune System

Stress comes in many forms, including physical or emotional events in our lives. This includes working long hours, demanding deadlines, financial anxieties, personal losses, trauma, physical injury, toxins, or infections. These ALL cause a stress response in our bodies.

And in turn, this stress response disrupts our healthy immune function.

We know that stress impacts our cortisol levels, causing them to be too high or too low. We also know that cortisol is always in communication with our immune system. When cortisol levels shift, so does the signal to the immune system. With long-standing stress, the immune system isn’t able to do its best work, plus, stress directly affects genetic expression, meaning stress turns on your genetic tendencies.

That’s why we are most susceptible to allergies, autoimmunity, infections, and cancer when we’ve been exposed to ongoing stress without enough stress recovery.

Examples of Stress and Immune-Related Health Issues in Studies (reference below)…

However, the answer is NOT to stop being students or to attempt to avoid all stress. That would be impossible. Stress is all around us, and actually, HUMANS ARE BUILT TO BE STRESSED.

It is simply a matter of making sure we also give our bodies what they need to recover from stress, including rest, nutritious food, water, nurturing, exercise, and nutrients. And to expose our bodies to the signals it needs so that our immune system has a chance to work for us, instead of against us.

By doing this, by helping our bodies to recover from stress, we can actually change our genetic expression. We can turn off autoimmunity and allergies. We can reset our immune system to where it functions best.

6 Steps to Reset Your Immune System

1. Practice Self-CARE

2. Nutrients and Antioxidants to Support the Immune System

In my experience (and based on research), the best nutrients to support healthy immune function are:

  1. Vitamin C – see Dr. Doni’s Vitamin C Support.
    In addition to supporting immune function, vitamin C is an anti-oxidant, helping our bodies recover from inflammation and oxidative stress.
  2. Zinc – see Dr. Doni’s Zinc Support 
    Just as with vitamin C, zinc is also an anti-oxidant and is involved is hundreds of metabolic processes related to healing.
  3. Vitamin A – see an example here
    Vitamin A is directly anti-viral in addition to being needed for healthy antibody production. It’s made from beta-carotene in our diet, but many of us have genetic variations that decrease conversion from beta-carotene, making actual vitamin A more effective. If you’re pregnant, you’ll want to stay under 10,000 iu, but otherwise, clinical doses can be used to support immune function.
  4. Vitamin D – see Dr. Doni’s Vitamin D & K Support 
    Vitamin D has so many functions in our bodies, including supporting healthy cytokine and bradykinin levels. We get vitamin D from sun exposure, but at least 20% of people are deficient in vitamin D (I see deficiencies much more often than 20%). Be sure to have your levels checked in your next blood work.
  5. NAC and Glutathione – see an example NAC here and glutathione here.
    N-acetylcysteine (NAC) is the amino acid cysteine (which our body can make from methionine) in a form we can take it as a supplement. It is one of the precursor nutrients for making glutathione (which we can also take as a supplement). Both are important as anti-oxidants, helping our bodies to heal for oxidative stress and inflammation. Additional, NAC has been shown to be directly anti-viral and to inhibit cytokines.

You can get Vitamin A, Vitamin C, and Zinc in one capsule in Dr. Doni’s Immune Support.

3. Herbs to Support a BALANCED Immune Response

In addition to nutrients, herbs* may support healthy immunity and to protect us from viruses and other pathogens, such as:

  1. Echinacea
  2. Astragalus
  3. Andrographis
  4. Quercetin

You can get the first 3 herbs all in Dr. Doni’s Immune Support. Here is an example (and my favorite) quercetin product.

4. Beneficial Proteins, Amino Acids, and Peptides

Protein, which is broken down into amino acids, are necessary for healthy cell production and immune function. This is one of the reasons I emphasize getting enough protein with each meal, which can require extra diligence if you are following a plant-based diet. Peptides, which are small chains of amino acids, and in particular the specific peptides that signal to the DNA in our cells to reset function, can be profoundly beneficial to immune function.

5. Gut Health Is Essential

50% of our immune system is based in our gutthat’s a BIG deal! If we have leaky gut or are on medications that negatively affect gut health and bacteria, our immune system becomes “confused” from the mixed signals.

To help rebalance our gut health, I suggest eliminating the inflammatory triggers from food allergens. This starts with an elimination diet (there is one inside my Stress Remedy Program) and/or doing a food sensitivity panel (can be done at home) so you can know exactly which foods to eliminate based on your results.

Once you have removed the foods causing stress to your gut, you can work to heal your leaky gut and balance gut bacteria.

You can order my Leaky Gut Support powder to help heal your intestinal walls.

6. Help Your Adrenal Glands Recover From Stress

Finally, the last step is to help our adrenals recover from stress. The best indicator of this is to actually check your cortisol and adrenaline levels throughout the day.

Once you have that information, you can use nutrients, herbs, and peptides that all help to re-optimize and reset your adrenal cortisol and adrenaline levels after stress exposure. My Dr. Doni Adrenal Support contains many of those essential herbs and nutrients.

You can also sign up for my Healing Leaky Gut with Dr. Doni (Online Course). It includes the 48 food panel I recommend (above) PLUS support from me in online sessions and a one-on-one meeting. This will help you implement my protocol. Here’s some more info, and how to sign up:

Get More Info

You CAN Do This!

For decades I had severe allergies – to foods, dust, pollen, and more – plus autoimmune conditions are common on both sides of my family. It took time but I eventually used these same six steps to recover from stress and reset my immunity.

Your body WILL respond to these positive steps so don’t give up because a healthy immune system is one of the most valuable things we can have in life – and it’s worth the effort of obtaining and maintaining it.

And that’s what I want for you, too.

Above all else, I want you to know that you CAN “boost”… or rather, balance and reset… your immune system to support and protect your health.

You deserve to change your health destiny – and I’m here to help every step of the way.

Wellness wishes to you, always!

–Dr. Doni
16th April 2020


*Please keep in mind that any and all supplements – nutrients, herbs, enzymes, or other – should be used with caution. My recommendation is that you seek the care of a naturopathic doctor (with a doctorate degree from a federally-accredited program) and that you have a primary care physician or practitioner whom you can contact to help you with individual dosing and protocols. If you ever experience negative symptoms after taking a product, stop taking it immediately and contact your doctor right away.


  1. Rondanelli M, Miccono A, Lamburghini A, Avanzato I, Riva A, Allegrini P, Faliva M, Peroni G, Nichetti M, Perna S. Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds—Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evidence-Based Complementary and Alternative Medicine. Volume 2018. Article ID 5813095.
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